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It regulates satiation through action on the area postrema (brain area outside blood-brain barrier) and nucleus tractus solitarius (NTS)

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The British National Formulary (BNF) states: For people with neurological involvement Initially administer hydroxocobalamin 1 mg intramuscularly on alternate days until there is no further improvement, then administer hydroxocobalamin 1 mg intramuscularly every 2 months

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