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GSH could detoxify heterogeneous substances under the catalysis of Glutathione S-transferases (GST), then secrete them via the multidrug resistance associated proteins (MRPs) efflux pump ( 3 GSH-responsive and -exhausting metal nanomaterials 3.1 Inorganic nanomaterials Inorganic nanomaterials that have intrinsically unique physicochemical properties and can provide satisfactory functionality show enormous potential in biomedical applications, especially in cancer therapy (Wang et al., 2021a)
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