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This prominent water-soluble constituent of Salvia miltiorrhiza Bunge, demonstrates a broad spectrum of pharmacological activities, including potent antioxidant, anti-inflammatory, and neuroprotective effects ( To address this knowledge gap, this study investigates the protective effects of SalA against sodium iodate (NaIO 3 )-induced ferroptosis in RPE cells and elucidates the underlying molecular mechanisms via the SLC7A11/GPX4 axis ( in vitro and in vivo models, molecular biology, and transcriptomic analysis, we demonstrate that SalA attenuates ferroptosis by upregulating SLC7A11 and GPX4 expression, thereby offering a novel therapeutic strategy for AMD
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